Application note
Application Note: Tablet Production Scale-Up Review
A reference framework for comparing batch preparation and tablet-compression equipment during scale-up.
Scope and limitations
This reference note describes a selection method and does not identify a completed customer project. Scale-up decisions should be based on formulation data and qualified process trials.
Scale-up inputs
The review begins with batch size, bulk density, flow, compressibility, granulation route, target tablet geometry, tablet weight, hardness range, and expected changeover frequency. These inputs connect preparation equipment to the tablet press rather than treating each machine separately.
Balance downstream stages
Downstream dedusting, inspection, metal detection where required, and coating capacity must be balanced against the sustained tablet-press output. Cleaning access and tooling strategy often have more practical impact than the maximum press speed.
Document the model shortlist
A model shortlist should document assumptions, process tests still required, utilities, containment requirements, tooling scope, and the acceptance criteria for factory testing.
Turn the requirement into an equipment shortlist.
Share your material, format, capacity, utilities, and destination standard for a model-level review.
Request a technical discussionContinue the technical review
Related equipment
Rotary Tablet Press
The YOKO-GY-D rotary tablet press is intended for pharmaceutical tablets and nutraceutical tablets. Selection is reviewed against prepared powder and granules, target output, utilities, and line interfaces. Final configuration is defined in the quotation and technical agreement.
- Reference range
- Model-dependent; see technical specifications
Rotary Tablet Press
The YOKO-Y-D rotary tablet press is intended for pharmaceutical tablets and nutraceutical tablets. Selection is reviewed against prepared powder and granules, target output, utilities, and line interfaces. Final configuration is defined in the quotation and technical agreement.
- Reference range
- Model-dependent; see technical specifications
Automatic Sugar Coating Machine
The YOKO-BY-M automatic sugar coating machine is intended for film coating and sugar coating. Selection is reviewed against tablets and pellets, target output, utilities, and line interfaces. Final configuration is defined in the quotation and technical agreement.
- Reference range
- 0.5-1 / 10-25 / 30-50 / 70-150 kg/batch
Automatic Tablet Coating Machine
The YOKO-JB-E automatic tablet coating machine is intended for film coating and sugar coating. Selection is reviewed against tablets and pellets, target output, utilities, and line interfaces. Final configuration is defined in the quotation and technical agreement.
- Reference range
- Model-dependent; see technical specifications
Elevating Tablet Deduster
The YOKO-SPJ-D elevating tablet deduster is intended for post-compression tablet handling and pre-coating or pre-packaging dedusting. Selection is reviewed against compressed tablets and tablets with removable surface dust, target output, utilities, and line interfaces. Final configuration is defined in the quotation and technical agreement.
- Reference range
- 300,000 / 550,000 / 3,000,000 / 1,000,000 pcs/hr
Pharmaceutical Dry Granulator
The YOKO-GZ-H pharmaceutical dry granulator is intended for tablet granulation and capsule formulation. Selection is reviewed against powders and binders, target output, utilities, and line interfaces. Final configuration is defined in the quotation and technical agreement.
- Reference range
- 2-10 / 20-60 / 30-80 / 50-100 / 80-200 kg/hr