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YOKO-XGS-S
Antibiotic Vial Filling and Stoppering Machine
YOKO-XGS-S is a liquid filling and stoppering family with two source-table configurations. The listed references are 20 bottles per minute with two filling heads and 35–40 bottles per minute with four heads; the table identifies 50 mL for one model and 50–500 mL for the other. Because the source uses both vial and bottle terminology, the actual container drawing, closure, process, and hygienic requirement must be confirmed before selection.
- Reference capacity / range
- 20 / 35-40 bottles/min
- Dimensions
- Confirmed for the selected configuration
- Power
- Confirmed for the selected configuration
Typical applicationCompatible pharmaceutical liquid filling into confirmed container formats · Vial or bottle projects after drawing and closure verification
Material or formatFree-flowing or selected viscous liquids after dosing trials · Compatible glass or plastic containers confirmed by drawing and samples
Equipment purpose
What this machine is designed to do
The equipment is intended to meter a compatible liquid into prepared containers and place the specified stopper or closure in a controlled indexed sequence. It may form part of an antibiotic, pharmaceutical, or other liquid-filling line only after the product-contact path, container handling, environmental controls, cleaning method, and required validation are defined.
Operating sequence
Working principle
Containers are fed and indexed beneath two or four filling nozzles, depending on model. A configured dosing system dispenses the programmed volume before containers move to stopper placement and discharge. Filling consistency and line efficiency depend on liquid viscosity and foaming, dose, container tolerances, stopper presentation, nozzle movement, product head conditions, air removal, change parts, and the upstream and downstream balance.
Review points
- Two listed configurations provide two or four filling heads and reference outputs of 20 or 35–40 containers per minute.
- The source table lists filling-accuracy references of ±1.5% and ±2%; project acceptance must define dose, sample plan, method, and operating conditions.
- Container detection and no-container/no-fill logic can reduce product loss when included in the configured controls.
- Container and stopper feeding must be tested with production-intent samples across their dimensional tolerances.
- A compact filler does not by itself establish an aseptic process; room classification, sterilization, interventions, contamination control, and validation remain project-specific.
- A sustained trial should record fill results, stopper placement, container damage, rejects, alarms, product loss, cleaning access, and line efficiency.
Process fit
Applications and compatible materials
Use these references to frame the first technical discussion. Suitability is confirmed with actual material, format, and process data.
Typical applications
- Compatible pharmaceutical liquid filling into confirmed container formats
- Vial or bottle projects after drawing and closure verification
- Small- to medium-output filling and stoppering lines
- Clean or controlled-area installation when defined by the user's process requirements
Material or format references
- Free-flowing or selected viscous liquids after dosing trials
- Compatible glass or plastic containers confirmed by drawing and samples
- Compatible elastomeric stoppers or specified closures
- Product-contact seals, tubing, and components selected for the formulation and cleaning method
Reference parameters
Technical specifications
Values are model references for initial selection. The quotation and approved technical agreement define the final supplied configuration.
Technical specifications
| Model | YOKO-2-1-1XGS-S / YOKO-4-1-1XGS-S |
|---|---|
| Capacity (bottles/min) | 20 / 35-40 |
| Applicable Bottle Specification (mL) | 50 / 50-500 |
| Filling Heads | 2 / 4 |
| Filling Accuracy | ±1.5% / ±2% |
| Power Supply | Configured for the destination electrical standard |
Before quotation
Configuration inputs
A useful quotation starts with the product, container or format, target output, available utilities, and destination requirements.
- Two-head or four-head reference configuration selected from dose and output
- Dosing principle, product vessel, level control, tubing, nozzles, and anti-drip arrangement
- Container and stopper feeding, change parts, format range, and reject handling
- Product-contact materials, hygienic finish, cleaning, sterilization, or single-use scope as required
- Controlled-area, LAF, RABS, or isolator interfaces only where specified by the process design
- Upstream washing or preparation, downstream capping or inspection, controls, documentation, and FAT criteria
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Request documentsSupporting files
Videos and technical documents
Availability varies by model and configuration. Request the current demonstration, datasheet, layout, or documentation package when needed.
Datasheet or manual
Download YOKO technical datasheetModel-specific operating manuals and layout files are supplied after configuration review.
Selection questions
Frequently asked questions
Is YOKO-XGS-S for vials or bottles?
The source product name says vial, while its technical table says bottle and lists 50 mL for one configuration and 50–500 mL for the other. Do not select from the name alone. Provide dimensioned container and stopper drawings, samples, material, neck finish, dose, headspace, and downstream closure method so the applicable format and machine arrangement can be confirmed.
How should the listed filling accuracy be evaluated?
The table lists ±1.5% for the two-head model and ±2% for the four-head model, but it does not define every test condition. The project protocol should state product, nominal dose, measurement method, tare handling, sampling frequency, startup exclusion, speed, product temperature, acceptance calculation, and treatment of rejected or incomplete fills.
Can YOKO-XGS-S fill viscous or foaming liquids?
Possibly, after a material trial and dosing review. Provide viscosity across the operating-temperature range, density, surface tension, foaming, particulates, shear sensitivity, dose, permitted product loss, cleaning agents, and product-contact compatibility. The pump, tubing, nozzle bore, dive profile, cutoff, and product-head control are then selected from those conditions.
Does the machine itself make the process aseptic?
No. Aseptic suitability depends on the complete process: component preparation and transfer, sterilization or sanitization, environmental classification, barrier system, product path, interventions, monitoring, operator practices, cleaning, hold times, and validation. These requirements must be specified separately and designed into the integrated line and facility.
What samples are needed before a filling and stoppering FAT?
Provide representative containers and stoppers across expected tolerances, enough liquid or an agreed surrogate with similar dosing behaviour, closure components, and any trays or feed parts. Define dose, accuracy method, run duration, speed, stopper-placement criteria, container-damage limits, reject challenges, alarms, cleaning demonstration, and upstream or downstream interface checks.
Continue the line review
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Model-level review
Request a configured quotation for YOKO-XGS-S
Share the material, product format, target sustained output, available utilities, destination standard, and expected documentation scope.
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