Technical datasheet
Download YOKO technical datasheetThis catalogue reference is not an operating manual. Final values are confirmed in the quotation and technical agreement.
Supplied by YOKO
YOKO-FDG-B
Large Pharmaceutical Freeze Dryer
YOKO-FDG-B is a pharmaceutical freeze-dryer family with reference shelf areas from 1 to 51 m² and configurations listing up to 17 operating shelf layers plus an additional shelf. The catalogue includes CIP- and SIP-identified variants for selected sizes. Final selection must connect vial or bulk format, fill depth, formulation, freezing method, condenser and vacuum performance, loading pattern, cycle development, utilities, closure handling, and the intended qualification scope.
- Reference capacity / range
- Confirmed for the selected product and format
- Dimensions
- Model-dependent; see technical specifications
- Power
- Confirmed for the selected configuration
Typical applicationLyophilized injectable products after process validation · Vaccines and biological materials
Material or formatFrozen liquid formulations in compatible containers · Vials with validated stoppers and loading patterns
Equipment purpose
What this machine is designed to do
The system removes water from a frozen product by sublimation under vacuum and completes secondary drying at controlled shelf conditions. It is intended for pharmaceutical, biological, diagnostic, and other validated applications where product stability requires low-temperature dehydration and controlled residual moisture.
Operating sequence
Working principle
Product is loaded onto temperature-controlled shelves and frozen according to the developed cycle. Chamber pressure is reduced so ice sublimes during primary drying while shelf heat supplies the latent energy; secondary drying then reduces bound moisture under a different temperature and pressure profile. Product temperature, shelf temperature, chamber pressure, condenser capacity, heat transfer, fill depth, and resistance through the dried cake determine cycle behaviour.
Review points
- Eleven reference configurations cover shelf areas from 1 to 51 m² for staged scale comparison.
- Shelf-layer count, chamber footprint, compressed-air demand, and machine weight vary substantially across the family.
- CIP, SIP, hydraulic, and stopper-closing details are configuration-specific and must be stated explicitly in the supply scope.
- A usable capacity calculation includes vial dimensions, loading clearance, fill volume, batch pattern, and cycle time rather than shelf area alone.
- Cycle development and equipment qualification are separate workstreams that must align on sensors, records, calibration, alarms, and acceptance tests.
- The facility review should address refrigeration heat rejection, condenser performance, vacuum exhaust, clean utilities, loading access, and maintenance space.
Process fit
Applications and compatible materials
Use these references to frame the first technical discussion. Suitability is confirmed with actual material, format, and process data.
Typical applications
- Lyophilized injectable products after process validation
- Vaccines and biological materials
- Diagnostic reagents and laboratory products
- Antibiotics or other temperature-sensitive formulations
Material or format references
- Frozen liquid formulations in compatible containers
- Vials with validated stoppers and loading patterns
- Compatible bulk trays where the configured system permits
- Cleaning and sterilization media defined for the selected configuration
Reference parameters
Technical specifications
Values are model references for initial selection. The quotation and approved technical agreement define the final supplied configuration.
Technical specifications
| Model | YOKO-1FDG-B (CIP+SIP) / YOKO-1.1FDG-B (CIP+SIP) / YOKO-3FDG-B (with hydraulic) / YOKO-3FDG-B (CIP+SIP) / YOKO-5FDG-B / YOKO-5FDG-B (CIP+SIP) / YOKO-10FDG-B / YOKO-20FDG-B (CIP) / YOKO-30FDG-B (CIP) / YOKO-30FDG1-B / YOKO-50FDG-B |
|---|---|
| Total Usable Area of Shelves (m²) | 1 / 1.1 / 3 / 3 / 5 / 5 / 10 / 20 / 30 / 29.7 / 51 |
| Board Layers | 4+1 / 4+1 / 6+1 / 6+1 / 6+1 / 6+1 / 7+1 / 11+1 / 10+1 / 11+1 / 17+1 |
| Max. Temperature of Shelf (°C) | 80 / 80 / 80 / 80 / 80 / 80 / 80 / 80 / 80 / 80 / 80 |
| Power Supply | Configured for the destination electrical standard |
| Compressed Air | ≥0.1m³/min (P=0.5-0.8 MPa) / ≥0.1m³/min (P=0.5-0.8Pa) / ≥40 L/min (P=0.5–0.8 MPa) / ≥40 L/min (P=0.5-0.8 MPa) / ≥0.1m³/min (P=0.5-0.8 MPa) / ≥0.1m³/min (P=0.5-0.8 MPa) / ≥0.1m³/min (P=0.5-0.8 MPa) / ≥0.1m³/min (P=0.5-0.8 MPa) / ≥0.1m³/min (P=0.5-0.8 MPa) / ≥0.1m³/min (P=0.5-0.8 MPa) / ≥0.1m³/min (P=0.5-0.8 MPa) |
| Dimensions (L*W*H mm) | 2850 × 1060 × 2500 / 3200 × 1560 × 2700 / 3200 × 1250 × 3000 / 4600 × 1620 × 2800 / 4000 × 1600 × 3200 / 5000 × 2000 × 3300 / 5400 × 1900 × 3300 / 5800 × 2200 × 3600 / 8000 × 2200 × 3500 / 8000 × 2300 × 2600 / 8500 × 2700 × 5000 |
| Approx. Weight (kg) | 2000 / 2000 / 2800 / 4500 / 5000 / 8000 / 8000 / 12000 / 15000 / 15000 / 25000 |
Before quotation
Configuration inputs
A useful quotation starts with the product, container or format, target output, available utilities, and destination requirements.
- Shelf area, shelf spacing, loading format, batch pattern, and stopper-closing requirement
- Refrigeration, condenser, vacuum, and control architecture for the intended cycle
- CIP, SIP, drainage, clean-steam, water, and compressed-air interfaces where required
- Temperature and pressure sensors, data records, calibration, alarms, and recipes
- Manual, cart-based, or integrated loading and unloading arrangement
- FAT, installation, commissioning, qualification documents, spares, and cycle-support scope
Need a model-specific file set?
Start an inquiry for the current selection data, layout information, and privately supplied follow-up files.
Request documentsControlled technical information
Public datasheet and private follow-up files
The public datasheet supports initial selection. Machine videos, operating manuals, and layout files are shared privately after an inquiry and technical discussion.
Video and operating documentation
Machine videos and operating manuals are not published on public product pages. Ask your YOKO contact to supply relevant files privately after the project requirement has been reviewed.
Start a technical inquirySelection questions
Frequently asked questions
How should shelf area be converted into batch capacity?
Use the actual vial outer diameter, loading clearance, tray or loading pattern, number of usable shelves, fill volume, and any excluded edge area. Shelf area alone cannot determine saleable units per batch. The proposed loading map should be reviewed together with the cycle and stopper-closing arrangement.
Does a CIP or SIP label define the complete cleaning and sterilization scope?
No. The scope should identify which chamber, condenser, piping, filters, valves, sensors, and drains are included; the cleaning media, clean-steam quality, cycle parameters, spray coverage, condensate handling, and documentation must also be defined. A model suffix is not a substitute for an approved process description.
Which product data is needed to size YOKO-FDG-B?
Provide formulation type, container and stopper, fill volume and depth, initial concentration, target residual moisture, freezing behaviour, proposed loading pattern, batch size, target cycle time, maximum product temperature, existing development data, room classification, and utility conditions. Heat-load and condenser assumptions should remain traceable.
What should a freeze-dryer FAT demonstrate?
The FAT can verify mechanical completion, controls, alarms, recipes, sensor checks, shelf-temperature behaviour, vacuum performance, condenser operation, leak-rate testing, hydraulic or stopper functions, and configured cleaning or sterilization sequences. Product-cycle performance requires an agreed load and protocol and may continue during site qualification.
Which facility utilities have the greatest effect on the project?
Electrical supply, cooling water or other heat-rejection service, refrigeration conditions, compressed air, vacuum exhaust, clean steam and water where applicable, drainage, HVAC classification, and loading logistics all affect installation. Their available temperature, pressure, flow, and quality should be confirmed before final design.
Continue the line review
Related equipment
Compact Laboratory Freeze Dryer
The YOKO-XDG-Z compact laboratory freeze dryer is intended for pharmaceutical freeze drying and biological materials. Selection is reviewed against frozen liquid products and frozen solid products, target output, utilities, and line interfaces. Final configuration is defined in the quotation and technical agreement.
- Reference range
- ≥4 / ≥8 / ≥15 / ≥20 / ≥30 kg
Lab Vacuum Freeze Drying Machine
The YOKO-XDG-O lab vacuum freeze drying machine is intended for pharmaceutical freeze drying and biological materials. Selection is reviewed against frozen liquid products and frozen solid products, target output, utilities, and line interfaces. Final configuration is defined in the quotation and technical agreement.
- Reference range
- Model-dependent; see technical specifications
Laboratory Freeze Dryer
The YOKO-XDG-A laboratory freeze dryer is intended for pharmaceutical freeze drying and biological materials. Selection is reviewed against frozen liquid products and frozen solid products, target output, utilities, and line interfaces. Final configuration is defined in the quotation and technical agreement.
- Reference range
- Model-dependent; see technical specifications
Industrial Food Freeze Dryer
The YOKO-SDG-B industrial food freeze dryer is intended for pharmaceutical freeze drying and biological materials. Selection is reviewed against frozen liquid products and frozen solid products, target output, utilities, and line interfaces. Final configuration is defined in the quotation and technical agreement.
- Reference range
- Confirmed for the selected product and format
Model-level review
Request a configured quotation for YOKO-FDG-B
Share the material, product format, target sustained output, available utilities, destination standard, and expected documentation scope.
info@sxyoko.com