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YOKO-YGF-K
Automatic Prefilled Syringe Filling and Stoppering Machine
YOKO-YGF-K is an automatic filling and stoppering family for prepared prefilled syringes. The reference range includes one-, two-, and five-head configurations, common syringe volumes from 0.5 to 20 mL depending on model, and listed capacities from 600 to 3,600 syringes per hour. Selection requires the actual syringe and stopper, product characteristics, filling path, environmental strategy, vacuum stoppering requirement, accuracy method, and downstream handling plan.
- Reference capacity / range
- 600-900 / 1200-1800 / 2400-3600 pcs/hr
- Dimensions
- 800 × 700 × 1730 / 1088 × 858 × 1800 / 1880 × 3950 × 1860 mm
- Power
- Confirmed for the selected configuration
Typical applicationReady-to-fill prefilled syringe processing · Compatible liquid pharmaceutical products
Material or formatCompatible pharmaceutical liquids · Validated viscous or gel formulations where specified
Equipment purpose
What this machine is designed to do
The system is intended to fill compatible liquids or validated viscous products into ready-to-fill syringe barrels and insert the stopper with controlled handling. It supports projects that need a repeatable bridge between component preparation and downstream inspection, plunger-rod assembly, labelling, or secondary packaging.
Operating sequence
Working principle
Syringe barrels are fed or presented in the required orientation and indexed to one or more filling heads. A configured metering system delivers the dose, after which the stopper is positioned and inserted, with vacuum assistance where specified to reduce trapped air and stopper friction. Performance depends on barrel and stopper tolerances, silicone condition, product rheology, dose, pump selection, filling speed, environmental control, and component presentation.
Review points
- One-, two-, and five-head references allow capacity to be compared with syringe format and project scale.
- Published syringe sizes are model-dependent; long and standard barrel formats must be checked against actual samples.
- Ceramic plunger pumping is a reference configuration whose suitability depends on product compatibility and cleaning requirements.
- Vacuum-assisted stoppering can reduce trapped air and component friction when correctly matched to the stopper and barrel.
- Filling accuracy is listed by model and must be verified using the agreed measurement method and production-intent components.
- The process boundary should identify who supplies component preparation, environmental control, inspection, rod insertion, labelling, and qualification.
Process fit
Applications and compatible materials
Use these references to frame the first technical discussion. Suitability is confirmed with actual material, format, and process data.
Typical applications
- Ready-to-fill prefilled syringe processing
- Compatible liquid pharmaceutical products
- Validated gel or ointment-like products on a suitable configuration
- Small- to medium-output syringe filling and stoppering projects
Material or format references
- Compatible pharmaceutical liquids
- Validated viscous or gel formulations where specified
- Ready-to-fill syringe barrels in approved formats
- Matched elastomeric stoppers and downstream assembly components
Reference parameters
Technical specifications
Values are model references for initial selection. The quotation and approved technical agreement define the final supplied configuration.
Technical specifications
| Model | YOKO-1YGF-K / YOKO-2YGF-K / YOKO-5GF-K |
|---|---|
| Applicable Materials | liquid and ointment / liquid and ointment / liquid and ointment |
| Applicable Syringe Specifications (mL) | 0.5, 1, 2.25, 3, 5, 10, 20 / 0.5, 1, 2.25, 3, 5, 10, 20 / 1 (Long),1, 2.25, 3 (standard), 5, 10 |
| Number of Filling Heads | 1 / 2 / 5 |
| Number of Plugging Heads | 1 / 2 / 5 |
| Filling Accuracy | ≤±1% / ≤±1% / ≤±1.5-2% |
| Capacity (pcs/hr) | 600-900 / 1200-1800 / 2400-3600 |
| Power Supply | Configured for the destination electrical standard |
| Compressed Air | 0.55-0.75 MPa 15 L/S / 0.55-0.75 MPa 15 L/S / 0.55-0.75 MPa 40 L/S |
| Dimensions (mm) | 800 × 700 × 1730 / 1088 × 858 × 1800 / 1880 × 3950 × 1860 |
| Weight (kg) | 300 / 500 / 1900 |
Before quotation
Configuration inputs
A useful quotation starts with the product, container or format, target output, available utilities, and destination requirements.
- Syringe format range, feeding method, nest or bulk handling, and change parts
- Pump, filling heads, product path, nozzles, and filling profile
- Stopper feeding, vacuum stoppering, insertion depth, and component checks
- Product-contact materials, cleaning, sterilization, and environmental interface
- Inspection, reject, plunger-rod assembly, labelling, and tray or conveyor transfer
- Records, alarms, recipes, FAT, qualification documents, spares, and destination utilities
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Request documentsSupporting files
Videos and technical documents
Availability varies by model and configuration. Request the current demonstration, datasheet, layout, or documentation package when needed.
Datasheet or manual
Download YOKO technical datasheetModel-specific operating manuals and layout files are supplied after configuration review.
Selection questions
Frequently asked questions
Which syringe formats can YOKO-YGF-K process?
The catalogue lists common formats from 0.5 to 20 mL, but coverage differs by model. Send drawings and samples for the barrel, flange, tip, stopper, and nest or tray where applicable. Long-barrel and standard formats can require different handling, so the approved format list must be part of the technical agreement.
How is filling accuracy confirmed for a prefilled syringe?
Agree the nominal dose, allowable variation, sampling plan, measurement method, product temperature, priming method, run speed, and treatment of startup units. Gravimetric or volumetric methods may give different uncertainty depending on density and dose. Accuracy should be verified with the intended pump, nozzle, product, and syringe.
Why is vacuum used during stopper insertion?
Vacuum can help control the air space and reduce the force needed to position a stopper without a plunger rod pushing it through the barrel. The required vacuum level, insertion depth, stopper lubrication, barrel silicone, product headspace, and acceptable bubble condition should be established with actual components.
Does YOKO-YGF-K include an aseptic processing environment?
Not unless the quotation explicitly includes it. The machine, restricted-access or isolator system, component preparation, transfer, filtration, cleaning, sterilization, environmental monitoring, interventions, and qualification responsibilities must be defined as one process. Regulatory suitability cannot be inferred from stainless-steel construction or a filling-machine model alone.
What should be supplied for a syringe filling trial?
Provide enough production-intent syringes and stoppers for setup and the agreed run, plus product or a representative material with documented viscosity and density. Include drawings, storage conditions, target dose, stopper position, bubble acceptance, speed, sampling, reject criteria, cleaning expectations, and any downstream interface that affects discharge.
Continue the line review
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Model-level review
Request a configured quotation for YOKO-YGF-K
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