Empty HPMC Capsules, Sizes 00–4

Start with target fill mass, bulk and tapped density, flow, dosing method, permissible compaction, ingredient volume, and any pellets or multiple fills. The table's density-based weights are useful estimates, not guaranteed fill weights. Trial the formulation in candidate sizes and confirm closing, weight variation, appearance, and package fit before final selection.

They are nominal capsule-volume references for sizes 4 through 00. Usable volume can be lower because the formulation must be dosed and the capsule closed correctly. Powder aeration, compression, plug length, pellets, tooling, and fill method change the achieved mass. Use the table for initial sizing and a filling trial for confirmation.

Often they can, but compatibility should not be assumed. Confirm capsule dimensions, locking geometry, shell condition, tooling, vacuum, orientation, separation, closing force, speed, and environmental conditions. Run production-intent shells and formulation to check separation failures, dents, splits, telescoping, unlocked capsules, and reject rate.

Only after a specific compatibility and sealing assessment. Provide the liquid composition, water activity, solvent system, viscosity, dose, shell contact time, proposed sealing method, package barrier, and storage conditions. Some fills may soften, embrittle, leak through, or interact with the shell, so a stability programme is required before commercial use.

Define size, colour, print artwork, shell and dimensional specification, packing quantity, liner and moisture protection, sample quantity, approved test methods, certificate requirements, microbiological or chemical limits, storage, shelf-life basis, destination requirements, and change-notification expectations. Final requirements belong in the approved purchase specification.